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About glucovance (Glyburide(glibenclamide)-Metformin)

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What is/are Glucovance Tablets?

GLYBURIDE; METFORMIN helps to treat type 2 diabetes. Treatment is combined with a diet and exercise. This medicine helps your body to use insulin better. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care providers before I take this medicine?

They need to know if you have any of these conditions:

• diabetic ketoacidosis
• become easily dehydrated
• heart disease
• if you frequently drink alcohol containing drinks
• kidney disease
• liver disease
• polycystic ovaries
• serious infection or injury
• stroke
• thyroid disease
• undergoing surgery or certain x-ray procedures with injectable contrast agents
• an unusual or allergic reaction to glyburide, metformin, sulfa drugs, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine?

Take this medicine by mouth with meals. Swallow with a drink of water. Follow the directions on the prescription label. Take your medicine at the same time each day. Do not take more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Patients over 65 years old may need a smaller dose than younger adults.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

Note: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

• bosentan
• cimetidine
• cisapride
• cyclosporine
• digoxin
• dofetilide
• entecavir
• fluconazole
• medicines for fungal or yeast infections
• metoclopramide
• morphine
• nifedipine
• other medicines for diabetes
• procainamide
• quinine
• quinidine
• ranitidine
• trimethoprim
• vancomycin
• warfarin

Many medications may cause an increase or decrease in blood sugar, these include:

• alcohol containing beverages
• aspirin and aspirin-like drugs
• chloramphenicol
• chromium
• female hormones, like estrogens or progestins and birth control pills
• heart medicines
• isoniazid
• male hormones or anabolic steroids
• medicines for weight loss
• medicines for allergies, asthma, cold, or cough
• medicines for mental problems
• medicines called MAO Inhibitors like Nardil, Parnate, Marplan, Eldepryl
• niacin
• NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
• pentamidine
• phenytoin
• probenecid
• quinolone antibiotics like ciprofloxacin, levofloxacin, ofloxacin
• some herbal dietary supplements
• steroid medicines like prednisone or cortisone
• thyroid medicine
• water pills or diuretics

This list may not describe all possible interactions. Give your health care providers a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What side effects may I notice from this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

• breathing difficulties
• dark yellow or brown urine, or yellowing of the eyes or skin
• fever, chills, sore throat
• low blood sugar (ask your doctor or healthcare professional for a list of these symptoms)
• severe skin rash, redness, swelling, or itching
• unusual bleeding or bruising

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

• diarrhea
• dizziness
• headache
• heartburn
• infection
• nausea, vomiting
• stomach discomfort

This list may not describe all possible side effects.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. Learn how to check your blood sugar. Tell your doctor or health care professional if your blood sugar is high, you might need to change the dose of your medicine. If you are sick or exercising more than usual, you might need to change the dose of your medicine. Do not skip meals. Ask your doctor or health care professional if you should avoid alcohol. If you have symptoms of low blood sugar, eat or drink something containing sugar at once and contact your doctor or health care professional. Make sure family members know that you can choke if you eat or drink when you develop serious symptoms of low blood sugar, like seizures or unconsciousness. They must get medical help at once.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

Wear a medical identification bracelet or chain to say you have diabetes, and carry a card that lists all your medications.

Where should I keep this medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 25 degrees C (59 and 77 degrees F). Keep container tightly closed and protect from light. Throw away any unused medicine after the expiration date.
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